The global gRNA market size was valued at USD 503.74 million in 2023 and is predicted to be worth around USD 2780.68 million by 2033, expanding at a CAGR of 18.63% from 2024 to 2033.
Key Points
- The North America gRNA market size accounted for USD 272.02 million in 2023 and is predicted to cross around USD 1,515.47 million by 2033, at a CAGR of 18.73% from 2024 to 2033.
- North America dominated the market with the largest revenue share of 54% in 2023.
- Asia Pacific is expected to host the fastest growing market during the forecast period of 2024-2033.
- By product & service type, the products segment led the global market in 2023.
- By product & service type, the custom gRNA synthesis services segment is expected to grow significantly in the market during the forecast period.
- By gRNA type, the research-use segment dominated the market in 2023.
- By gRNA type, the GMP-grade segment is expected to gain a significant share of the market during the forecast period.
- By application type, the genome engineering segment dominated the market in 2023 and is expected to grow at the fastest rate during the forecast period.
- By end-use type, the pharmaceutical & biotechnology companies segment has held a major revenue share of 50% in 2023.
- By end-use type, the academic research institutes segment will grow at the fastest rate over the forecast period.
The gRNA market is integral to the broader landscape of gene editing technologies, particularly CRISPR-Cas systems. gRNA serves as a guide for Cas proteins to locate specific DNA sequences, enabling precise editing of genes. This technology has revolutionized genetic research, offering unprecedented capabilities in altering DNA sequences in various organisms, including humans, plants, and animals.
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Growth Factors
Several factors contribute to the growth of the gRNA market. Technological advancements in CRISPR-Cas systems, such as improved specificity and efficiency of gene editing, have expanded the applications of gRNA in research and therapeutic settings. Increasing investment in biotechnology and pharmaceutical sectors for genome editing research and development further drives market growth. Additionally, growing awareness and adoption of personalized medicine and genetic therapies propel demand for gRNA technologies.
Region Insights
The gRNA market is globally distributed, with North America and Europe leading in terms of research and development activities and market adoption. These regions benefit from robust biotechnology infrastructure, significant investment in genome editing research, and supportive regulatory frameworks. Asia-Pacific is witnessing rapid growth due to increasing investments in biotechnology, rising prevalence of genetic disorders, and expanding healthcare infrastructure.
gRNA Market Scope
| Report Coverage | Details |
| Market Size by 2033 | USD 2780.68 Million |
| Market Size in 2023 | USD 503.74 Million |
| Market Size in 2024 | USD 597.59 Million |
| Market Growth Rate from 2024 to 2033 | CAGR of 18.63% |
| Largest Market | North America |
| Base Year | 2023 |
| Forecast Period | 2024 to 2033 |
| Segments Covered | Product & Service Type, gRNA Type, Application, End-use and Regions |
| Regions Covered | North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa |
gRNA Market Dynamics
Drivers
Key drivers of the gRNA market include the expanding applications in biomedical research, agriculture, and biotechnology industries. The ability of gRNA to facilitate precise genetic modifications with high efficiency has spurred its adoption in developing therapeutic treatments for genetic disorders and infectious diseases. Moreover, advancements in delivery technologies for CRISPR-Cas systems enhance the therapeutic potential of gRNA-based treatments.
Opportunities
The gRNA market presents substantial opportunities for innovation and growth. Continuous advancements in CRISPR-Cas technology, including novel gRNA designs and delivery methods, offer potential for expanding applications in gene therapy, agricultural biotechnology, and drug discovery. Collaborations between academic institutions, biotechnology companies, and pharmaceutical firms can accelerate the development of gRNA-based therapies and commercialization efforts.
Challenges
Despite promising growth prospects, the gRNA market faces challenges such as off-target effects during gene editing, regulatory complexities surrounding genome editing technologies, and ethical considerations related to human germline editing. Developing efficient and safe delivery systems for CRISPR-Cas components, including gRNA, remains a significant challenge for therapeutic applications. Addressing these challenges will be crucial for realizing the full potential of gRNA in clinical and commercial settings.
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gRNA Market Companies
- Synthego
- Horizon Discovery Ltd
- Synbio Technologies
- Takara Bio Inc.
- GENEWIZ (Azenta Life Sciences)
- Merke KGaA
- Jena Bioscience GmbH
- System Biosciences, LLC
- Agilent Technologies Inc.
- Thermo Fischer Scientific Inc.
- Revvity Inc. (Horizon Discovery Ltd)
Recent Developments
- In October 2023, a leading provider of genome engineering solutions, Synthego, launched its transformative product, IND-enabling (INDe) gRNAs, which helps to bridge critical preclinical gaps to promote CRISPR-based gene and cell therapies. This innovation offers researchers a high-quality designed gRNA, especially for IND-enabling and GLP-regulated preclinical studies, including complete IND-compliant documentation and materials in their production and design.
- In May 2024, in Dubai, a pioneer in genomic research & technology, BioAro officially launched a revolutionary software, “PanOmiQ,” the world’s fastest multi-genomic analysis solutions. It helps to reduce health risks.
Segments Covered in the Report
By Product & Service Type
- Products
- gRNA Final Products
- gRNA Synthesis Products
- gRNA Synthesis Kits
- Plasmids
- Others
- Custom gRNA Synthesis Services
By gRNA Type
- Research-use
- GMP-grade
By Application
- Genome Engineering
- Disease Model Studies
- Functional Genomics
- Epigenetics
- Others
By End-use
- Pharmaceutical & Biotechnology Companies
- Academic Research Institutes
- CMOs & CROs
By Geography
- North America
- Asia Pacific
- Europe
- Latin America
- Middle East & Africa
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